Geriatric use: Clinical studies of Nembutal have not included sufficient numbers of subjects aged 65 and over to determine whether elderly subjects respond differently mild younger subjects. Other reported clinical experience has anmärkning identified differences in responses between the elderly and younger patients. In Fältherre, dose selection for an elderly patient should bedja cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, knipa of concomitant disease or other drug therapy.
The effect of the resultant decreased blood levels of griseofulvin on therapeutic response has anmärkning been established. However, it would vädja preferable to avoid concomitant administration of these drugs.
pentobarbital will decrease the level or effect of ramelteon ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will decrease the level or effect of dexamethasone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
pentobarbital will decrease the level or effect of aprepitant ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Skärm.
However, the application of these Uppgifter to other barbiturates appears valid knipa warrants serial blood level determinations of the relevant drugs when there are multiple therapies.
pentobarbital will decrease the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Datorskärm Closely. Recommended atogepant dosage with concomitant use of stark or moderate CYP3A4 inducers is 30 mg or 60 mg qDay.
Special patient population: Dosage should bedja reduced in the elderly or debilitated because these patients may vädja more sensitive to barbiturates. Dosage should vädja reduced for patients with impaired renal function or hepatic disease.
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pentobarbital will decrease the level or effect of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the level or effect of pantoprazole ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
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pentobarbital increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Skärm Closely. Coadministration of buprenorphine knipa benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, knipa death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases.
pentobarbital will decrease the level or effect of etravirine samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Skärm.